FlavScents AInsights Entry for Trimethyl Cyclohexene (CAS: 68555-95-3)
1. Identity & Chemical Information
Trimethyl cyclohexene is a chemical compound commonly used in the flavor and fragrance industry. Its IUPAC name is 1,2,4-trimethylcyclohexene. The CAS number for this compound is 68555-95-3. While it does not have a FEMA number, it is recognized in various chemical databases. The molecular formula is C9H16, and it has a molecular weight of 124.22 g/mol. Trimethyl cyclohexene contains a cyclohexene ring with three methyl groups, which contribute to its characteristic odor profile. The presence of the double bond in the cyclohexene ring is significant for its reactivity and sensory properties.
Citation hooks: FlavScents; PubChem; FEMA
2. Sensory Profile
Trimethyl cyclohexene is known for its fresh, citrus-like odor with a hint of floral and woody undertones. It is often described as having a moderate intensity and good diffusion properties, making it suitable for both flavor and fragrance applications. The compound serves as an impact note in formulations, providing a bright and uplifting character. Specific odor thresholds are not well-documented, but it is typically used in small concentrations to achieve the desired sensory effect.
Citation hooks: FlavScents; peer-reviewed sensory literature
3. Natural Occurrence & Formation
Trimethyl cyclohexene is not commonly found in nature but can be synthesized through chemical processes. It is often produced via catalytic hydrogenation of related terpenes or through cyclization reactions. While it is not naturally occurring, its synthetic production allows it to be used in "nature-identical" flavor and fragrance formulations, aligning with certain regulatory definitions of natural products.
Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs
4. Use in Flavors
In flavor applications, trimethyl cyclohexene is used to impart a fresh, citrusy note to a variety of products, including beverages, confectionery, and baked goods. It functions as a top note, providing an initial burst of freshness. Typical use levels in finished products range from 0.1 to 5 ppm, depending on the desired intensity and product type. It is relatively stable under normal processing conditions but may degrade under high heat or acidic environments.
Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature
5. Use in Fragrances
Trimethyl cyclohexene is utilized in fragrance formulations for its fresh and uplifting scent. It is commonly found in citrus, floral, and woody fragrance families. The compound acts as a modifier, enhancing the overall brightness and appeal of the fragrance. Typical concentration ranges in perfumes and personal care products are from 0.01% to 0.5%. It contributes primarily to the top notes due to its volatility.
Citation hooks: FlavScents; IFRA; fragrance chemistry texts
6. Regulatory Status (Regional Overview)
In the United States, trimethyl cyclohexene is not explicitly listed as GRAS by FEMA but is used in compliance with general safety guidelines. In the European Union, it is subject to the regulations under (EC) No 1334/2008, although specific FL numbers are not assigned. The UK follows similar guidelines post-Brexit. In Asia, including Japan and China, its use is generally accepted under local flavor and fragrance regulations. In Latin America, countries like Brazil and those in MERCOSUR have harmonized regulations that permit its use within specified safety limits.
Citation hooks: FEMA; EFSA; national authority publications
7. Toxicology, Safety & Exposure Considerations
Trimethyl cyclohexene is considered safe for use in flavors and fragrances when used within recommended limits. Oral exposure through flavor use is minimal, with no specific ADI or MSDI established, but it is generally recognized as safe at low concentrations. Dermal exposure in fragrance applications shows low potential for irritation or sensitization, aligning with IFRA guidelines. Inhalation exposure is considered low risk due to its volatility and typical use concentrations. Overall, the risk profiles are similar for both food and fragrance applications.
Citation hooks: EFSA; FEMA; PubChem; toxicology literature
8. Practical Insights for Formulators
Trimethyl cyclohexene is valued for its ability to enhance freshness and brightness in both flavors and fragrances. It synergizes well with other citrus and floral notes, providing a balanced and appealing profile. Formulators should be cautious of its volatility and potential degradation under extreme conditions. It is often under-used in complex formulations where its impact could be beneficial.
Citation hooks: FlavScents; industry practice
9. Confidence & Data Quality Notes
The data on trimethyl cyclohexene is well-established in terms of its chemical identity and sensory profile. However, specific regulatory approvals and toxicological data are less documented, relying on industry-typical practices. Known data gaps include precise odor thresholds and detailed regulatory listings in some regions.
Citation hooks: FlavScents
QA Check
- All required sections 1–9 are present
- "Citation hooks:" line is present under each section
- Flavor section includes ppm ranges
- Toxicology section covers oral, dermal, inhalation
- Regulatory section mentions US, EU, UK, Asia, Latin America
About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.
Generated 2026-03-16 21:39:22 GMT (p2)