FlavScents AInsights Entry for 2,2'-methylene bis(6-(1-methyl cyclohexyl)-para-cresol) (CAS: 77-62-3)

1. Identity & Chemical Information

• Common Name(s): Antioxidant 425
• IUPAC Name: 2,2'-methylene bis(6-(1-methylcyclohexyl)-para-cresol)
• CAS Number: 77-62-3
• FEMA Number: Not applicable
• Other Identifiers: Not available
• Molecular Formula: C23H32O2
• Molecular Weight: 340.50 g/mol

2,2'-methylene bis(6-(1-methyl cyclohexyl)-para-cresol) is a synthetic antioxidant characterized by its phenolic structure, which contributes to its ability to stabilize free radicals. This compound is primarily used to prevent oxidation in various applications, including food and fragrance formulations.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

This compound does not have a significant odor or flavor profile, as its primary function is as an antioxidant rather than a sensory agent. It is typically used in formulations where its sensory impact is minimal, allowing other components to define the product's sensory characteristics.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

2,2'-methylene bis(6-(1-methyl cyclohexyl)-para-cresol) is a synthetic compound and does not occur naturally. It is produced through chemical synthesis, typically involving the reaction of cresol derivatives with formaldehyde. As a synthetic antioxidant, it does not qualify for "natural flavor" or "natural fragrance" designations.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

This compound is not typically used directly in flavor formulations due to its lack of sensory properties. However, it may be included in flavor systems as an antioxidant to enhance the stability and shelf life of flavor compounds. Typical use levels in food are not well-documented, but industry practices suggest minimal concentrations sufficient to achieve desired antioxidant effects.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance applications, 2,2'-methylene bis(6-(1-methyl cyclohexyl)-para-cresol) serves as an antioxidant to prevent the degradation of volatile fragrance components. It is used across various fragrance families and product types, including perfumes and personal care products. Concentration levels are typically low, as its primary role is functional rather than sensory.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not listed as FEMA GRAS; used as an antioxidant in non-food applications.
• European Union: Not specifically listed under Regulation (EC) No 1334/2008 for flavor use.
• United Kingdom: Follows EU regulations post-Brexit; no specific divergence noted.
• Asia: Limited specific regulatory information; generally follows international guidelines for antioxidants.
• Latin America: Regulatory status varies; typically used in non-food applications.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Not typically used in food applications; therefore, oral exposure data is limited.
• Dermal Exposure: Generally considered safe in low concentrations for use in personal care products; no significant irritation or sensitization reported.
• Inhalation Exposure: Low volatility reduces inhalation risk; primarily used in non-volatile applications.

Overall, the compound is considered safe for its intended uses, with a low risk profile in both food and fragrance applications.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

2,2'-methylene bis(6-(1-methyl cyclohexyl)-para-cresol) is valued for its antioxidant properties, which help maintain the integrity of formulations by preventing oxidation. It is often used in synergy with other antioxidants to enhance stability. Formulators should be cautious of overuse, as excessive concentrations may lead to regulatory scrutiny or unintended interactions with other formulation components.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on 2,2'-methylene bis(6-(1-methyl cyclohexyl)-para-cresol) is well-established in terms of its chemical identity and functional role as an antioxidant. However, specific sensory and regulatory data are less documented, reflecting its primary use in non-sensory applications.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges (not applicable due to non-sensory use)
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-04-23 07:08:14 GMT (p2)