FlavScents AInsights Entry for N-(2-methyl cyclohexyl)-2,3,4,5,6-pentafluorobenzamide (CAS: 1003050-32-5)

1. Identity & Chemical Information

• Common Name(s): Not widely known by a common name.
• IUPAC Name: N-(2-methylcyclohexyl)-2,3,4,5,6-pentafluorobenzamide
• CAS Number: 1003050-32-5
• FEMA Number: Not available
• Other Identifiers: No FL number, CoE number, or IFRA reference available
• Molecular Formula: C13H14F5NO
• Molecular Weight: 295.25 g/mol

This compound features a cyclohexyl group substituted with a methyl group and a pentafluorobenzamide moiety. The presence of the pentafluorobenzamide group suggests potential for unique odor characteristics due to the electron-withdrawing nature of the fluorine atoms, which can influence volatility and sensory perception.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

N-(2-methyl cyclohexyl)-2,3,4,5,6-pentafluorobenzamide is expected to exhibit a complex sensory profile due to its unique chemical structure. The odor descriptors might include notes of freshness and subtle floral or herbal nuances, although specific sensory data is not readily available. The intensity and diffusion are likely moderate, given the molecular weight and structure.

Taste and odor thresholds have not been clearly reported, necessitating empirical testing for precise formulation use. Typically, such compounds serve as modifiers or impact notes in fragrance compositions, enhancing complexity and depth.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

This compound does not occur naturally and is synthesized for specific applications. The formation involves chemical synthesis pathways that incorporate fluorination techniques, often used to enhance stability and modify sensory properties.

As a synthetic compound, it does not qualify for "natural flavor" or "natural fragrance" designations, which may limit its use in certain regulatory contexts where natural labeling is required.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

N-(2-methyl cyclohexyl)-2,3,4,5,6-pentafluorobenzamide is not commonly used in flavor applications due to its synthetic nature and lack of natural occurrence. However, it could theoretically be used in niche applications where its unique sensory properties are desired.

Typical use levels in flavors are not documented, but industry-typical estimates suggest usage in trace amounts (below 1 ppm) to avoid overpowering other flavor components. Stability under various conditions such as heat and pH is expected to be robust due to the fluorinated structure, which resists oxidation.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance applications, this compound may find use in modern, synthetic compositions. It could contribute to fragrance families such as fougère or chypre, where its fresh and potentially herbal notes can enhance complexity.

Typical concentration ranges are not well-documented, but it is likely used in trace to low concentrations, contributing as a modifier or impact note. Its volatility suggests a role in the middle to base notes of a fragrance composition.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not listed under FEMA GRAS; specific regulatory status for flavor use is unclear.
• European Union: Not explicitly listed under Reg. (EC) No 1334/2008; lacks an FL number.
• United Kingdom: Post-Brexit alignment with EU regulations is assumed, but specific divergence is not documented.
• Asia: No specific information available for Japan, China, or ASEAN regions.
• Latin America: Regulatory status in Brazil and MERCOSUR regions is not clearly reported.

Overall, the regulatory landscape for this compound is characterized by a lack of explicit approvals, necessitating careful consideration by formulators.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Data not found for ADI, TTC, or MSDI. Given its synthetic nature, oral exposure should be minimized.
• Dermal Exposure: Potential for irritation or sensitization is not well-documented; IFRA guidelines should be consulted for fragrance use.
• Inhalation Exposure: Volatility suggests potential for inhalation exposure; occupational safety measures should be considered.

Risk profiles may differ between food and fragrance applications, with greater caution advised for oral exposure due to limited toxicological data.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

This compound's value lies in its unique sensory profile, offering potential for innovation in fragrance formulations. It may synergize well with other synthetic materials to create novel scent profiles. Formulators should be cautious of its synthetic nature and regulatory limitations, ensuring compliance with regional guidelines.

Common pitfalls include overuse, leading to overpowering effects, and underestimating its impact in complex formulations.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data for N-(2-methyl cyclohexyl)-2,3,4,5,6-pentafluorobenzamide is limited, with much of the information being industry-typical but undocumented. Known data gaps include specific sensory thresholds and comprehensive toxicological profiles. Regulatory ambiguities further complicate its use in formulations.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-08-26 06:08:13 GMT (p2)