AInsights Entry for Neopentyl Glycol Dioctanoate (CAS: 28510-23-8)

1. Identity & Chemical Information

• Common Name(s): Neopentyl glycol dioctanoate
• IUPAC Name: 2,2-dimethylpropane-1,3-diyl dioctanoate
• CAS Number: 28510-23-8
• FEMA Number: Not applicable
• Other Identifiers: Not available
• Molecular Formula: C21H40O4
• Molecular Weight: 356.54 g/mol

Neopentyl glycol dioctanoate is an ester compound characterized by its two octanoate groups attached to a neopentyl glycol backbone. The ester functional groups contribute to its stability and low volatility, making it suitable for various applications in flavors and fragrances. Its structure is significant for its odor profile, providing a subtle, long-lasting scent.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Neopentyl glycol dioctanoate is known for its mild, waxy odor with a hint of fruity undertones. It is not typically used for its flavor but rather for its ability to modify and stabilize other sensory components. The compound's low volatility results in a subtle diffusion, making it an excellent background note in complex formulations. Specific odor and taste thresholds are not well-documented, but its role is primarily as a modifier rather than a primary impact note.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Neopentyl glycol dioctanoate is a synthetic compound and does not occur naturally. It is typically produced through the esterification of neopentyl glycol with octanoic acid. This synthetic origin means it does not qualify for "natural flavor" or "natural fragrance" designations under most regulatory frameworks.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Neopentyl glycol dioctanoate is used in flavor systems primarily as a stabilizer and modifier. It is not a primary flavoring agent but can enhance the longevity and stability of other volatile compounds. Typical use levels in finished food or beverage products are not well-documented, but industry practices suggest low ppm levels, often below 10 ppm, to avoid altering the primary flavor profile. It is stable under a range of conditions, including varying pH and moderate heat, making it versatile in different formulations.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance applications, neopentyl glycol dioctanoate is valued for its fixative properties, helping to prolong the presence of more volatile fragrance components. It is commonly used in personal care products and fine fragrances, contributing to the base notes due to its low volatility. Typical concentration ranges are from 0.1% to 1% in finished products, depending on the desired effect and product type.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not specifically listed by FEMA as GRAS for flavor use. Its use in fragrances is subject to general safety regulations.
• European Union: Not listed under Regulation (EC) No 1334/2008 for flavor use. Its use in cosmetics and fragrances is regulated under the EU Cosmetics Regulation.
• United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
• Asia: Specific regulations in Japan and China are not well-documented; typically follows international safety standards.
• Latin America: Generally follows international guidelines, but specific national regulations may vary.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

Neopentyl glycol dioctanoate is considered safe for use in both flavors and fragrances at typical usage levels. Oral exposure through flavor use is minimal due to low concentrations. Dermal exposure in fragrances is generally safe, with no significant reports of irritation or sensitization. Inhalation exposure is low risk due to its low volatility. Overall, the compound has a favorable safety profile, with no significant differences in risk between food and fragrance applications.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Neopentyl glycol dioctanoate is valued for its ability to stabilize and extend the life of volatile compounds in both flavors and fragrances. It synergizes well with fruity and floral notes, enhancing their longevity without overpowering the primary scent or flavor. A common pitfall is overuse, which can lead to a waxy or oily residue in the final product. It is often under-utilized in formulations where stability is a concern.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on neopentyl glycol dioctanoate is well-established in terms of its chemical identity and general safety profile. However, specific sensory thresholds and detailed regulatory approvals are less documented, reflecting industry-typical practices rather than explicit regulatory guidance. Known data gaps include detailed toxicological studies and comprehensive regulatory listings in some regions.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-04-14 10:46:21 GMT (p2)