FlavScents AInsights Entry for 1-Acetyl Cyclohexyl Acetate (CAS: 52789-73-8)

1. Identity & Chemical Information

• Common Name(s): 1-Acetyl Cyclohexyl Acetate
• IUPAC Name: 1-Acetylcyclohexyl acetate
• CAS Number: 52789-73-8
• FEMA Number: Data not found
• Other Identifiers: Data not found
• Molecular Formula: C10H16O3
• Molecular Weight: 184.23 g/mol

1-Acetyl cyclohexyl acetate is a single chemical compound characterized by its ester functional group, which is crucial for its odor profile. The presence of the acetyl group contributes to its distinctive scent, often associated with fruity and floral notes. The cyclohexyl ring structure provides a degree of stability and influences the compound's volatility and diffusion properties.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

1-Acetyl cyclohexyl acetate is known for its pleasant, fruity, and floral odor, often described as reminiscent of apple or pear with a subtle floral undertone. The intensity of its scent is moderate, making it suitable for use as a background note or modifier in fragrance compositions. The compound's diffusion is balanced, allowing it to blend well with other fragrance components without overpowering them.

Taste and odor thresholds for 1-acetyl cyclohexyl acetate are not clearly reported in the literature. However, its sensory role is typically as a modifier, enhancing the overall complexity and realism of a fragrance or flavor profile.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

1-Acetyl cyclohexyl acetate is not commonly found in nature and is primarily synthesized for use in flavor and fragrance applications. Its formation typically involves the esterification of cyclohexanol with acetic anhydride or acetyl chloride, a process that can be controlled to yield high purity and consistency.

Due to its synthetic origin, 1-acetyl cyclohexyl acetate does not qualify for "natural flavor" or "natural fragrance" designations under most regulatory frameworks, which require components to be derived from natural sources.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

1-Acetyl cyclohexyl acetate is utilized in various flavor categories, including fruit and floral profiles. It serves as a functional modifier, adding depth and complexity to flavor systems. Typical use levels in finished food or beverage products are not well-documented, but industry practice suggests low to moderate ppm ranges, depending on the desired intensity and application.

The compound is relatively stable under typical food processing conditions, including moderate heat and pH variations. However, it may be susceptible to oxidation, which can alter its sensory characteristics over time.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In the fragrance industry, 1-acetyl cyclohexyl acetate is valued for its ability to impart a fresh, fruity, and floral character. It is commonly used in fragrance families such as fruity florals and green florals, and is found in product types ranging from fine perfumes to personal care products.

The compound typically functions as a middle note, providing a bridge between top and base notes. Its volatility is moderate, contributing to its role as a modifier and impact note in fragrance compositions. Concentration ranges vary, but it is generally used at low levels to achieve the desired olfactory effect.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not explicitly listed as FEMA GRAS; usage should comply with general safety standards.
• European Union: Not specifically listed under Regulation (EC) No 1334/2008; usage should align with general safety and labeling requirements.
• United Kingdom: Follows EU regulations post-Brexit; no specific divergence noted.
• Asia: Limited specific data; general safety and labeling standards apply.
• Latin America: Limited specific data; general safety and labeling standards apply.

Explicit approvals for 1-acetyl cyclohexyl acetate are not well-documented, and formulators should ensure compliance with harmonized safety assumptions and regional regulations.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Data not found for ADI, TTC, or MSDI; formulators should adhere to industry-typical safety margins and conduct thorough risk assessments.
• Dermal Exposure: Limited data on irritation and sensitization; IFRA guidelines should be consulted for safe use in fragrances.
• Inhalation Exposure: Volatility suggests potential for inhalation exposure; occupational safety measures should be considered in manufacturing settings.

The risk profile for 1-acetyl cyclohexyl acetate may differ between food and fragrance applications, with dermal and inhalation routes being more relevant for fragrance use.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

1-Acetyl cyclohexyl acetate is valued for its ability to enhance the complexity and realism of both flavor and fragrance compositions. It synergizes well with other fruity and floral notes, providing a balanced and nuanced profile. Common formulation pitfalls include overuse, which can lead to an overpowering scent, and underuse, which may result in a lack of desired impact.

Formulators should consider the compound's stability and potential for oxidation when designing products, and ensure that it is used within safe and effective concentration ranges.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on 1-acetyl cyclohexyl acetate is relatively limited, with well-established sensory characteristics but less comprehensive regulatory and toxicological information. Industry-typical practices are often relied upon in the absence of explicit documentation, and formulators should be aware of potential data gaps and regulatory ambiguities.

Citation hooks: FlavScents

QA Check

• All required sections 1-9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-08-31 10:10:51 GMT (p2)