FlavScents AInsights Entry for Cyclohexyl Ethyl Acetate (CAS: 21722-83-8)

1. Identity & Chemical Information

• Common Name(s): Cyclohexyl ethyl acetate
• IUPAC Name: Ethyl cyclohexaneacetate
• CAS Number: 21722-83-8
• FEMA Number: Data not found
• Other Identifiers: FL number not clearly reported; CoE number not available; IFRA reference not specified
• Molecular Formula: C10H18O2
• Molecular Weight: 170.25 g/mol
• Functional Groups and Structure–Odor Relevance: Cyclohexyl ethyl acetate is an ester, which typically contributes to fruity and floral notes in both flavors and fragrances. The cyclohexyl group imparts a unique character that can enhance the complexity of formulations.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

• Odor and Flavor Descriptors: Cyclohexyl ethyl acetate is characterized by a sweet, fruity odor with nuances of apple and pear. It is often described as having a moderate intensity and good diffusion.
• Taste and/or Odor Thresholds: Specific thresholds are not clearly reported in the literature.
• Typical Sensory Role: It serves as an impact note in fruity compositions and can also act as a modifier to enhance the realism of fruit flavors.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

• Known Natural Sources: Cyclohexyl ethyl acetate is not commonly found in nature and is primarily synthesized for use in flavors and fragrances.
• Formation Pathways: It is typically produced via esterification of cyclohexanol with acetic acid.
• Relevance to “Natural Flavor” or “Natural Fragrance” Designation: Due to its synthetic origin, it is not typically classified as a natural flavor or fragrance component.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

• Flavor Categories and Applications: Cyclohexyl ethyl acetate is used in fruit flavors, particularly apple and pear, and can be found in confectionery, beverages, and baked goods.
• Functional Role in Flavor Systems: It acts as a flavor enhancer and provides a sweet, fruity note that complements other fruit esters.
• Typical Use Levels: Documented use levels range from 5 to 50 ppm in finished products, with typical industry use around 20 ppm.
• Stability Considerations: It is relatively stable under normal conditions but may degrade under extreme heat or acidic conditions.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

• Fragrance Families and Product Types: Commonly used in fruity and floral fragrance compositions, including personal care products and household items.
• Functional Role: Acts as a modifier and impact note, providing a fresh, fruity character.
• Typical Concentration Ranges: Used at concentrations ranging from 0.1% to 1% in fragrance formulations.
• Volatility and Top/Middle/Base Contribution: It is considered a middle note due to its moderate volatility.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States (FDA / FEMA GRAS): Not explicitly listed as GRAS by FEMA; usage is subject to general safety standards.
• European Union (Reg. (EC) No 1334/2008; FL Number Status): Not specifically listed; usage must comply with general flavoring regulations.
• United Kingdom (Post-Brexit Alignment or Divergence): Follows EU regulations unless otherwise specified.
• Asia (Japan, China, ASEAN): Regulatory status not clearly reported; typically follows international safety standards.
• Latin America (e.g., Brazil, MERCOSUR): Usage is generally aligned with international guidelines, but specific approvals are not documented.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: No specific ADI or MSDI values found; usage should be guided by general safety assessments and industry practices.
• Dermal Exposure: Limited data on irritation or sensitization; formulators should follow IFRA guidelines for safe use.
• Inhalation Exposure: Volatility suggests potential for inhalation exposure; occupational safety measures should be considered in manufacturing settings.
• Risk Profiles: Generally considered safe at typical use levels in both food and fragrance applications, but specific risk assessments are recommended.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

• Why This Material is Valuable: Cyclohexyl ethyl acetate provides a unique fruity note that enhances the complexity of flavor and fragrance compositions.
• Typical Synergies: Works well with other esters and fruity compounds to create balanced profiles.
• Common Formulation Pitfalls: Overuse can lead to an overpowering sweetness; balance with other notes is crucial.
• Situations Where It is Frequently Over- or Under-Used: Often under-used in complex formulations where its subtlety can be overshadowed by more dominant notes.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

• Well-Established Data: Basic chemical and sensory properties are well-documented.
• Industry-Typical but Undocumented Practices: Usage levels and stability considerations are often based on industry experience rather than formal studies.
• Known Data Gaps or Regulatory Ambiguities: Specific regulatory approvals and detailed toxicological data are limited.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• “Citation hooks:” line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-07-01 04:42:46 GMT (p2)