AInsights Entry for Isolongifolene Ketone (CAS: 23787-90-8)

1. Identity & Chemical Information

• Common Name(s): Isolongifolene ketone
• IUPAC Name: 2,2,6,6-Tetramethyl-1-oxaspiro[4.5]dec-3-en-8-one
• CAS Number: 23787-90-8
• FEMA Number: Not available
• Other Identifiers: Not available
• Molecular Formula: C15H24O
• Molecular Weight: 220.35 g/mol
• Functional Groups and Structure–Odor Relevance: Isolongifolene ketone is characterized by its spirocyclic ketone structure, which contributes to its unique woody and camphoraceous odor profile. The presence of the ketone group is significant for its olfactory properties, providing a distinctive sharpness and depth.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Isolongifolene ketone is known for its woody, camphoraceous, and slightly spicy odor. It is often described as having a robust and intense character with moderate diffusion. The compound is typically used as an impact note in fragrance compositions, providing a distinctive woody and earthy background. The odor threshold is not clearly reported, but it is generally recognized for its potent sensory impact even at low concentrations.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Isolongifolene ketone is not commonly found in nature but can be synthesized from isolongifolene, a sesquiterpene present in certain essential oils such as cedarwood oil. The formation of isolongifolene ketone typically involves oxidation processes. Its synthetic origin limits its designation as a "natural flavor" or "natural fragrance," although it can be used in formulations labeled as such if derived from natural precursors.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Isolongifolene ketone is used in flavor applications to impart woody and spicy notes, often in savory and spice blends. It serves as a background realism enhancer and is typically used at low concentrations, generally ranging from 0.1 to 5 ppm in finished food products. These values are industry-typical estimates, as specific documented ranges are not readily available. The compound is stable under typical food processing conditions, including moderate heat and pH variations.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance formulations, isolongifolene ketone is valued for its contribution to woody and oriental fragrance families. It acts as a modifier and impact note, often used in concentrations ranging from 0.1% to 1% in the final product. The compound is considered a base note due to its relatively low volatility, providing lasting depth and complexity to the fragrance composition.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not explicitly listed as FEMA GRAS; usage in flavors and fragrances is subject to general safety and regulatory compliance.
• European Union: Not specifically listed under Regulation (EC) No 1334/2008; usage must comply with general safety standards.
• United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
• Asia: Specific regulatory status in Japan, China, and ASEAN countries is not well-documented; general safety compliance is required.
• Latin America: Regulatory information for Brazil and MERCOSUR is limited; general safety and compliance with local regulations are necessary.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Data not found for specific ADI or MSDI values; usage should adhere to industry best practices and safety evaluations.
• Dermal Exposure: No specific IFRA restrictions reported; general safety assessments indicate low irritation potential.
• Inhalation Exposure: Volatility is moderate; occupational exposure should be managed with standard safety precautions.

The risk profile for isolongifolene ketone does not significantly differ between food and fragrance applications, assuming adherence to recommended usage levels.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Isolongifolene ketone is valued for its ability to impart a woody and earthy character to both flavors and fragrances. It synergizes well with other woody and spicy notes, enhancing the overall complexity of the formulation. Common pitfalls include overuse, which can lead to an overpowering camphoraceous quality. It is often underutilized in formulations seeking a subtle yet impactful woody background.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on isolongifolene ketone is well-established in terms of its sensory profile and functional roles. However, specific regulatory and toxicological data are less documented, necessitating reliance on industry-typical practices and safety evaluations. Known data gaps include precise usage levels and comprehensive regulatory approvals across all regions.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-08-19 07:05:33 GMT (p2)