FlavScents AInsights Entry for Cyclohexadecanone (CAS: 2550-52-9)

1. Identity & Chemical Information

• Common Name(s): Cyclohexadecanone
• IUPAC Name: Cyclohexadecanone
• CAS Number: 2550-52-9
• FEMA Number: Not available
• Other Identifiers: Not available
• Molecular Formula: C16H30O
• Molecular Weight: 238.41 g/mol

Cyclohexadecanone is a macrocyclic ketone, characterized by a 16-membered ring structure. The presence of the ketone functional group is significant for its odor profile, contributing to its musky scent. The large ring size is typical of compounds used in perfumery for their ability to impart long-lasting, diffusive fragrances.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Cyclohexadecanone is primarily noted for its musky odor, which is both rich and diffusive. It is often described as having a warm, animalic character with a subtle sweetness. The intensity of its scent is moderate, making it suitable for use as a background note that enhances the complexity of fragrance compositions. While specific taste or odor thresholds are not well-documented, its role as a musky base note is well-recognized in the industry.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Cyclohexadecanone is not commonly found in nature and is typically synthesized for use in fragrances. Its formation involves the cyclization of long-chain hydrocarbons, a process that can be achieved through various synthetic pathways. Due to its synthetic origin, cyclohexadecanone does not qualify for "natural flavor" or "natural fragrance" designations under most regulatory frameworks.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Cyclohexadecanone is not widely used in flavor applications due to its primary association with fragrance. However, when used, it can contribute a subtle muskiness to flavor profiles, particularly in complex formulations where a background note is desired. Typical use levels in food are not well-documented, but industry estimates suggest usage in the low ppm range. Its stability under various conditions, such as heat and pH, makes it a versatile component in flavor systems.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In perfumery, cyclohexadecanone is valued for its musky, animalic scent, which is a staple in many fragrance families, including oriental and woody compositions. It serves as a base note, providing longevity and depth to the fragrance. Typical concentration ranges in perfumes are from 0.1% to 1%, depending on the desired intensity. Its low volatility ensures a lasting presence, making it an essential component for creating enduring scents.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Cyclohexadecanone is not specifically listed by FEMA as GRAS for flavor use. Its use in fragrances is subject to general safety evaluations.
• European Union: Not explicitly listed under Regulation (EC) No 1334/2008 for flavor use. Its use in fragrances is regulated under the EU Cosmetics Regulation.
• United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
• Asia: Regulatory status varies; not widely documented for flavor use. Fragrance use is subject to national cosmetic regulations.
• Latin America: Limited specific data; generally follows international safety standards for fragrance use.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: Limited data available; not typically used in food applications.
• Dermal Exposure: Generally considered safe for use in cosmetics at typical concentrations. No significant irritation or sensitization reported.
• Inhalation Exposure: Low volatility reduces inhalation risk; occupational exposure should follow standard safety practices.

Overall, cyclohexadecanone is considered safe for use in fragrances, with no significant differences in risk profiles between food and fragrance applications due to its limited use in flavors.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Cyclohexadecanone is prized for its ability to impart a musky, animalic note that enhances the depth and complexity of fragrance compositions. It synergizes well with other base notes, such as amber and woody accords. Formulators should be cautious of its intensity, as overuse can overwhelm a fragrance. It is often under-utilized in flavor applications due to its primary association with perfumery.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on cyclohexadecanone is well-established in the context of fragrance use, with industry practices supporting its safety and efficacy. However, there are gaps in documented flavor use and specific regulatory approvals, which should be considered when formulating products.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-04-20 09:41:16 GMT (p2)