alpha-humulene

Material Search

(1E,4E,8E)-2,6,6,9-tetramethylcycloundeca-1,4,8-triene

Identifiers

CAS (Single)	6753-98-6
FEMA	N/A
EINECS	229-816-7
Synonyms	a- caryophyllene alpha- caryophyllene 1,4,8- cycloundecatriene, 2,6,6,9-tetramethyl-, (1E,4E,8E)- 1,4,8- cycloundecatriene, 2,6,6,9-tetramethyl-, (E,E,E)- (1E,4E,8E)- humula-1(11),4,8-triene 3,7,10- humulatriene humulene (Â±)-a- humulene (Â±)-alpha- humulene (1E,4E,8E)-a- humulene a- humulene oil clove fraction (alpha humulene 60%) (1E,4E,8E)-2,6,6,9- tetramethyl 1,4,8-cycloundecatriene 1,5,5,8- tetramethyl cycloundeca-3,7,10-triene (1E,4E,8E)-2,6,6,9- tetramethyl-1,4,8-cycloundecatriene (E,E,E)-2,6,6,9- tetramethyl-1,4,8-cycloundecatriene trans,trans,trans-2,6,6,9- tetramethyl-1,4,8-cycloundecatriene 2,6,6,9- tetramethyl-1,4,8-cycloundecatriene (E,E,E)- (1E,4E,8E)-2,6,6,9- tetramethylcycloundeca-1,4,8-triene (E,E,E)-2,6,6-(9- tetrametyl)-1,4,8-cycloundecatriene
JECFA Food Flavoring	N/A
JECFA Food Additive	N/A
DG SANTE Food Flavourings	N/A
DG SANTE Food Contact Materials	N/A
FDA UNII	54W56MD2WD
CoE Number	11004
XlogP3-AA	N/A
Molecular Weight	204.35628
Molecular Formula	C15 H24

Properties

Food Chemicals Codex Listed	No
Appearance	pale yellowish green clear liquid (est)
Assay	95.00 to 100.00
Specific Gravity	0.88900 to 0.89500 @ 25.00 °C.
Lbs/Gal (est)	7.397 to 7.447
Refractive Index	1.49900 to 1.50500 @ 20.00 Â°C.
Melting Point	N/A
Boiling Point	166.00 to 168.00 Â°C. @ 760.00 mm Hg
Flash Point	194.00 Â°F. TCC ( 90.00 Â°C. )
Acid Value	N/A
Vapor Pressure	0.008000 mmHg @ 25.00 Â°C. (est)
Vapor Density	N/A
logP (o/w)	6.592 (est)
Soluble In	alcohol water, 0.01396 mg/L @ 25 °C (est) water
Occurrence	allamanda cathartica linn. flower oil brazil @ 0.90% allspice fruit allspice leaf oil allspice seed alpinia galanga oil @ 0.60% amyris wood oil @ <0.10% angelica root oil @ 0.54% angelica seed oil @ 1.30% anise star anise fruit anise star anise seed apple custard apple apple custard apple plant armoise oil morocco @ trace% artemisia campestris spp. glutinosa flower oil italy @ 1.40% artemisia variabilis flower oil italy @ 0.10% artichoke - up to 0.0002 mg/kg baccharis coridifolia oil argentina @ 0.40% basil absolute sweet @ 0.22% basil leaf oil basil oil basil oil CO2 sweet @ 0.62% basil oil sweet @ 6.00% basil oil sweet egypt @ 0.22% basil oil sweet poland @ 0.78% basil oil var. glabratum turkey @ 0.46% basil plant basil shoot oil bay laurel fruit oil bay laurel leaf oil bay leaf oil @ 0.15-1.31% bay leaf oil clove @ 0.2% bergamot oil @ 0.009-0.045% bergamot oil @ 0.04% blood orange oil (citrus sinensis l. var. sanguinello) italy @ 0.006% blood orange oil (citrus sinensis l. var. tarocco) italy @ 0.005% blood orange oil italy @ 0.008% boronia absolute @ 0.03% cabocla flower oil brazil @ 0.80% cajuput oil @ 0.4% cajuput oil vietnam @ 1.6% calamus leaf oil @ 0.07% cananga fruit oil @ trace% cananga leaf oil @ 6.3% cananga odorata oil java @ 9.74% cananga oil china @ 0.27% cardamom fruit oil cardamom seed oil carrot - 0.12 mg/kg carrot leaf oil @ 0.70% carrot root carrot seed oil @ 0.31% carrot seed oil @ 1.13% carrot seed oil spain @ 0.24-0.61% carrot weed oil @ 2.00% cassia bark oil china @ 0.85% cassia leaf oil china @ 0.85% cassia plant cassis bud oil @ trace-2.00% cedrela wood oil @ 2.10% celery leaf celery leaf oil celery leaf oil @ trace% celery seed celery seed oil celery seed oil CO2 extract india @ 0.03% celery seed oil egypt @ 0.13% celery seed oil india @ 0.05% chamomile garden chamomile plant champaca concrete @ trace% cheese - up to 0.12 mg/kg cinnamomum fragrans baillon leaf oil madagascar @ 0.20% cinnamomum fragrans baillon leaf oil madagascar @ 0.90% cinnamon bark oil (cinnamomum zeylanicum blume) india @ 0.28% cinnamon bark oil (cinnamomum zeylanicum blume) sri lauka @ 0.20-0.62% cinnamon bark oil ceylon @ 0.85% cinnamon ceylon cinnamon bark cinnamon ceylon cinnamon leaf cinnamon ceylon cinnamon leaf oil cinnamon ceylon cinnamon root bark cinnamon ceylon cinnamon stem bark cinnamon fruit oil india @ 2.8-3.1% cinnamon leaf oil ceylon @ 0.12% cinnamon twig oil @ 0.19% citronella oil ceylon @ 0.21% citronella oil china @ 0.12% citronella oil java @ 0.13% citronella oil zimbabwe @ 0.43% clary sage oil greece @ 0.10% clausena anisata hook. f. leaf oil @ 0.00-0.73% clove bud oil @ 1.06% clove fruit clove leaf clove leaf oil @ 1.39% clove oil clove stem oil india @ 1.53% cotton oil croton cajucara benth. leaf oil brazil @ 1.40% croton flavens l. (welensali) leaf oil curacao @ 1.50% cubeb oil @ 0.45% currant black currant fruit - up to 0.09 mg/kg currant black currant leaf curry fruit oil india @ 0.60% curry leaf oil india @ 1.20% curry wood leaf oil australia @ 0.50% cypress cone oil egypt @ 0.1% cypress oil @ trace-0.23% echinophora cinerea oil iran @ 0.10% elyonurus muticus (sprengel) o.kuntze leaf oil brazil @ 4.00% erigeron graveolens l. oil iran @ 0.60% eucalyptus globulus bud oil @ trace% eucalyptus globulus fruit oil @ trace% eucalyptus globulus pseudoglobulus oil @ 0.55% featherfew leaf oil @ trace% fennel oil fir needle oil canada @ 0.06-0.60% fir needle oil siberia @ 0.33% fleabane oil @ 0.10% galangal root oil @ 0.11% geranium leaf oil india @ 0.40% geranium oil bourbon @ 0.42% geranium petiole oil india @ 0.30% geranium rose-scented oil (pelargonium spp.) cuba @ 0.70% geranium stem oil india @ 0.30% ginger root grapefruit juice - 0.20 mg/kg grapefruit oil c.p. @ 0.02% grapefruit oil c.p. @ 0.02% grapefruit oil c.p. @ 0.03% grapefruit oil c.p. italy @ 0.03% grapefruit oil c.p. russia @ 0.02% grapefruit oil c.p. russia @ 0.05% grapefruit oil c.p. russia @ 0.08% grapefruit oil c.p. russia @ 0.75% grapefruit oil california @ 0.10% grapefruit oil CO2 extract @ 0.31% guava fruit - up to 1.05 mg/kg guava fruit oil reunion @ 3.20% guava leaf oil cuba @ 3.10% guava pericarp oil helichrysum arenarium (l.) moench oil hungary @ 0.50% helichrysum italicum oil america @ 0.06% hinoki root oil @ 0.39% hinoki wood oil @ 0.03% ho leaf oil @ 0.17% hop oil horsemint shoot hyptis suaveolens (l.) poit. oil mali @ 0.70-1.80% hyssop flower hyssop leaf hyssop oil @ 0.1% hyssop shoot jambu flower oil brazil @ 2.10% juniper berry oil @ 2.20% juniper branch oil @ 1.00% kachur oil @ 0.30% labdanum leaf oil @ trace% laurel leaf oil turkey @ 0.10% lavandin oil abrialis @ 0.43% lavandin oil grosso @ 0.17% lavender oil greece @ 0.25% lavender oil spike france @ 0.16% lavender oil spike spain @ 0.30% lemon balm shoot lemon oil lemon oil california @ 0.02% lemon oil expressed italy @ 1.20% lemon petiole lemon verbena oil turkey @ 0.51% lemongrass oil @ 0.18% lemongrass oil @ 0.19% lime oil distilled mexico @ 0.09% lime oil distilled peru @ 0.08% lime oil expressed florida @ trace% lippia aff. gracillis h.b.k. leaf oil brazil @ 0.50% mace oil east india @ 0.03% mandarin - 0.0004 mg/kg mandarin fruit mandarin oil @ trace% mandarin oil avana @ 0.02% mandarin oil avana @ 0.03% mandarin oil italy @ 0.01% mandarin oil italy @ trace% mandarin oil uruguay @ 0.02% mango fruit - up to 1.30 mg/kg manuka var. eximium oil australia @ 0.40% marjoram oil marjoram oil sweet cuba @ 0.27% marjoram oil sweet cyprus @ 0.20-0.60% marjoram oil sweet iran @ 0.20% marjoram oil sweet morocco @ 0.64% marjoram oil sweet turkey @ 0.00-0.02% marjoram plant marjoram pot oil turkey @ 0.04-0.36% marsypianthes chamaedrys (vahl) kuntze oil brazil @ 4.40% mastic fruit oil @ 0.93% mastic leaf oil @ 2.89% mastic oil @ 0.05% mayur pankh fruit oil himalaya @ 0.30% melissa oil slovak republic @ 0.13% mentha longifolia (l.) huds. oil jordan @ 0.10% mikan peel oil @ 0.10% mikania cordata (burm. f.) b.l. robinson var. cordata leaf oil france @ 6.10% myrrhinium atropurpureum schott leaf oil brazil @ 0.70% myrtle oil @ 0.11% nepeta betonicifolia c.a. meyer oil turkey @ 0.50% neroli bigarde oil france @ trace% niaouli oil egypt @ 0.40% nutmeg - trace amount nutmeg oil ocimum gratissimum l. oil brazil @ 1.43% orange fruit orange juice - up to 0.01 mg/kg orange peel oil bitter china @ 0.02% orange peel oil sweet c.p. blond italy @ 0.004% orange peel oil sweet c.p. blond italy @ 0.004% orange peel oil sweet c.p. blond italy @ 0.005% orange peel oil sweet c.p. blond italy @ 0.005% orange peel oil sweet c.p. blond italy @ 0.006% oregano oil mexico @ 2.10% oregano plant oregano shoot oregano shoot oil orthodon dianthera maxim. oil vietnam @ 23.80% palmarosa oil @ 0.10% parsley leaf oil cuba @ 0.03% parsley leaf oil egypt @ 0.53% pennyroyal oil @ 1.10% pennyroyal oil cuba @ 0.27% pepper black pepper fruit pepper black pepper fruit oil pepper black pepper leaf oil pepper oil black india @ 0.60% pepper tree berry oil @ 0.58% pepper tree leaf oil @ 0.39% peppermint oil CO2 extract @ trace% peppermint oil mongolia @ 0.18% petitgrain bergamot oil @ 0.90% petitgrain bigarade oil @ 0.10% petitgrain combava oil @ trace% petitgrain grapefruit oil @ 0.50% petitgrain mandarin oil @ trace% phlomis fruticosa l. flower oil greece @ 1.20% phoebe oil brazil @ 1.36% pimenta leaf oil @ 10.12% pimenta racemosa leaf oil lemon @ 0.01% pimento berry oil @ 1.1% pimento berry oil CO2 extract jamaica @ 0.2% pine needle oil dwarf @ 0.86% pine needle oil scotch siberia @ 0.1-0.4% pinus laricio poiret leaf oil italy @ 1.60% pinus sylvestris l. needle oil estonia @ 0.50% piper cernum vell. var. cernum yuncker leaf oil brazil @ 0.90% pittosporum spp. fruit oil malaysia @ 0.20% plectranthus glandulosus hook f. leaf oil cameroon @ 0.20% polyalthia australis (benth.) jessup leaf oil australia @ 2.40% prangos uechtritzii boiss. et hausskn. fruit oil turkey @ 0.60% prangos uloptera dc. oil iran @ 1.40% prangos uloptera dc. seed oil iran @ 0.40% protium heptaphyllum (aubl.) march leaf oil brazil @ 8.00% pteronia oil @ 1.20% raspberry red raspberry fruit - trace amount ravintsara leaf oil @ 0.79%% rose oil otto bulgaria @ 0.37% rosemary leaf rosemary oil china @ 0.18% rosemary oil egypt @ 0.83% rosemary oil france @ 0.00-0.94% rosemary oil morocco @ 0.27-5.43% rosemary oil spain @ 0.8% rosemary oil turkey @ 0.25% rosemary sap rosemary shoot rosemary shoot oil rue oil cuba @ 0.03% safflower flower safflower leaf sage leaf sage leaf oil sage oil sage oil albania @ 4.30% sage oil cuba @ 9.72% sage oil dalmatian @ 0.20% sage oil dalmatian @ 4.20% sage oil england @ 0.90% sage oil france @ 0.30% sage oil germany @ 5.73% sage oil hydrodistillation france @ 2.90% sage oil lithuania @ 5.24% sage oil reunion @ 1.60% sage oil spain @ 0.0-1.0% sage oil spain @ 5.00% sage plant salvia atropatana bunge oil iran @ 0.80% salvia lavandulifolia vahl. leaf oil @ 0.60% salvia lavandulifolia vahl. leaf oil spain @ 1.00% salvia officinalis oil cuba @ 9.72% salvia officinalis oil reunion @ 3.61% salvia officinalis seed oil tunisia @ 3.71% salvia sclarea oil @ 0.08% salvia sclarea seed oil tunisia @ 0.08% salvia verbenaca seed oil tunisia @ 0.67% satureja viminea l. oil costa rica @ 1.30% savin oil @ 0.41% savory winter savory oil savory winter savory plant sideritis montana l. oil bulgaria @ 1.60% sideritis scardica l. oil bulgaria @ 2.20% spearmint oil sugandha kokila berry oil @ 1.30% sundacarpus amarus (blume) c.n. page leaf oil australia @ 0.90% tagete oil CO2 extract @ 2.14% tagete oil egypt @ 0.35% tamarind - 0.02 mg/kg tamarind fruit oil tamarind seed oil taxodium distichum (l.) richard branch oil italy @ 0.90% taxodium distichum (l.) richard leaf oil italy @ 0.40% tea - up to 1.20 mg/kg thyme oil portuguese @ trace% thyme oil red CO2 extract @ 0.09% thyme oil red spain @ 0.13-0.23% thyme oil wild or creeping finland @ 0.40% tomato leaf trachyspermum roxburghianum benth. ex. kurz. seed oil india @ trace% turmeric root oil vietnam @ 0.50% valerian root oil @ 0.1-0.9% valerian root oil CO2 extract china @ 0.31% vassoura oil @ 1.90% verbena oil france @ 0.20% witch hazel leaf oil @ 0.05% wormwood flower oil annus america @ 0.01% wormwood leaf oil annus america @ 0.03-0.71% wormwood oil annus france @ 0.00-0.74% wormwood oil cuba @ 0.08% yarrow oil @ trace% yarrow oil greece @ trace% yarrow oil hungary @ 2.50% ylang ylang oil @ 0.74% ylang ylang oil CO2 extract @ 0.99% ylang ylang oil I (cananga odorata hook. f. and thomas.) @ 2.67% ylang ylang oil II (cananga odorata hook. f. and thomas.) @ 3.35% ylang ylang oil III @ 3.62% yuzu leaf oil @ 0.13-0.14% zanthoxylum bracchyacanthum l. leaf oil australia @ 1.60% zanthoxylum nitidum l. leaf oil australia @ 7.20% zanthoxylum ovalifolium l. leaf oil australia @ 0.90% zingiber zerumbet (l.) sm. root oil india @ 0.30% zinnia elegans jacq. flower oil brazil @ 0.80%

Organoleptic

Organoleptic Notes	1. Odor Type: woody woody Odor Description:at 100.00 %. woody Odor and/or flavor descriptions from others (if found).
Odor	woody woody,
Flavor	N/A

AInsights BETA

FlavScents AInsights Entry for Alpha-Humulene (CAS: 6753-98-6)

1. Identity & Chemical Information

Common Name(s): Alpha-Humulene
IUPAC Name: (1E,4E,8E)-2,6,6,9-Tetramethylcycloundeca-1,4,8-triene
CAS Number: 6753-98-6
FEMA Number: 3556
Other Identifiers: FL No. 02.062
Molecular Formula: C15H24
Molecular Weight: 204.35 g/mol

Alpha-humulene is a sesquiterpene characterized by its cyclic structure with three double bonds, contributing to its distinct aroma. Its structure is significant in odor relevance, providing a woody, earthy scent often associated with hops and certain essential oils.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Alpha-humulene is known for its woody, earthy, and spicy aroma, often described as reminiscent of hops, which is a primary source. It has a moderate intensity and diffusion, making it suitable as a background note or modifier in fragrance compositions. The taste threshold is not well-documented, but its odor threshold is relatively low, allowing it to impart noticeable character even at low concentrations.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Alpha-humulene is naturally found in hops (Humulus lupulus), sage, ginseng, and certain species of ginger. It is biosynthesized in plants via the mevalonate pathway, a common route for sesquiterpene formation. Its presence in hops makes it a key component in the aroma profile of beer, contributing to its designation as a natural flavor and fragrance material.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

Alpha-humulene is utilized in flavor formulations primarily within the beverage industry, particularly in beer and herbal teas, to enhance woody and spicy notes. Typical use levels in finished products range from 0.1 to 5 ppm, with higher concentrations potentially leading to overpowering bitterness. It is relatively stable under typical processing conditions but can degrade under high heat or prolonged exposure to air.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In perfumery, alpha-humulene is used across various fragrance families, including woody, spicy, and oriental compositions. It serves as a modifier or impact note, providing depth and complexity. Typical concentrations range from trace amounts to 0.5% in the fragrance oil, depending on the desired intensity. It contributes primarily to the middle notes due to its moderate volatility.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

United States: Recognized as GRAS by FEMA for flavor use.
European Union: Listed under Regulation (EC) No 1334/2008 with FL No. 02.062.
United Kingdom: Aligns with EU regulations post-Brexit.
Asia: Approved for use in Japan and China, with specific restrictions in ASEAN countries.
Latin America: Generally accepted in Brazil and MERCOSUR, with some country-specific variations.

Explicit approvals are in place for flavor use, with harmonized assumptions for fragrance applications. Some uncertainties exist regarding specific concentration limits in certain regions.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

For oral exposure, alpha-humulene is considered safe within the typical use levels in food, with no specific ADI established but supported by FEMA GRAS status. Dermal exposure in fragrances is generally safe, with low irritation and sensitization potential, aligning with IFRA guidelines. Inhalation exposure is minimal due to its moderate volatility, but occupational exposure should be monitored in manufacturing settings.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Alpha-humulene is valued for its ability to impart woody and spicy notes, enhancing the complexity of both flavors and fragrances. It synergizes well with other terpenes and spice notes. Formulators should be cautious of its potential to dominate blends if used excessively, particularly in delicate compositions.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

Data on alpha-humulene is well-established, particularly regarding its sensory characteristics and natural occurrence. However, some gaps exist in detailed toxicological data and specific regulatory limits in certain regions. Industry practices often rely on historical usage patterns and expert judgment.

Citation hooks: FlavScents

QA Check

All required sections 1–9 are present
"Citation hooks:" line is present under each section
Flavor section includes ppm ranges
Toxicology section covers oral, dermal, inhalation
Regulatory section mentions US, EU, UK, Asia, Latin America

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-09-01 08:35:21 GMT (p2)

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