FlavScents AInsights Entry for Isocyclocitral (IFF) (CAS: 1335-66-6)

1. Identity & Chemical Information

• Common Name(s): Isocyclocitral
• IUPAC Name: 2,6,6-Trimethylcyclohex-2-en-1-carbaldehyde
• CAS Number: 1335-66-6
• FEMA Number: Data not found
• Other Identifiers: FL number not clearly reported; IFRA reference not found
• Molecular Formula: C10H16O
• Molecular Weight: 152.24 g/mol
• Functional Groups and Structure–Odor Relevance: Isocyclocitral contains an aldehyde group, which is often associated with fresh, citrus-like odors. The cyclohexene ring contributes to its stability and diffusion characteristics, making it a valuable component in fragrance formulations.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

• Odor and Flavor Descriptors: Isocyclocitral is characterized by a fresh, citrus-like odor with green and slightly floral nuances. It is known for its moderate intensity and good diffusion properties.
• Taste and/or Odor Thresholds: Specific thresholds are not clearly reported; however, it is typically used in low concentrations due to its potent odor.
• Typical Sensory Role: It serves as an impact note in both flavor and fragrance compositions, providing a fresh and vibrant top note.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

• Known Natural Sources: Isocyclocitral is not commonly found in nature and is primarily synthesized for use in flavors and fragrances.
• Formation Pathways: It is typically produced through synthetic pathways involving the cyclization of citral or related compounds.
• Relevance to “Natural Flavor” or “Natural Fragrance” Designation: Due to its synthetic origin, isocyclocitral does not qualify for natural flavor or fragrance designations.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

• Flavor Categories and Applications: Isocyclocitral is used in citrus, fruity, and floral flavor profiles. It is often employed in beverages, confectionery, and dairy products.
• Functional Role in Flavor Systems: It acts as a modifier and impact note, enhancing freshness and complexity.
• Typical Use Levels: Documented use levels range from 0.1 to 5 ppm in finished products, with typical industry use around 1 ppm.
• Stability Considerations: Isocyclocitral is relatively stable under normal conditions but may degrade under high heat or acidic conditions.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

• Fragrance Families and Product Types: Commonly used in citrus, floral, and green fragrance families. It is found in perfumes, colognes, and personal care products.
• Functional Role: Acts as a top note, providing freshness and lift to fragrance compositions.
• Typical Concentration Ranges: Typically used at concentrations of 0.1% to 1% in fragrance formulations.
• Volatility and Top/Middle/Base Contribution: Isocyclocitral is a volatile compound, contributing primarily to the top notes of a fragrance.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States (FDA / FEMA GRAS): Not explicitly listed as GRAS; usage is based on industry practices.
• European Union (Reg. (EC) No 1334/2008; FL Number Status): Not clearly reported; assumed to be used under general flavoring principles.
• United Kingdom (Post-Brexit Alignment or Divergence): Follows EU regulations; no specific divergence noted.
• Asia (Japan, China, ASEAN): High-level data not found; typically follows international standards.
• Latin America (e.g., Brazil, MERCOSUR): Data not found; generally aligns with international practices.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

• Oral Exposure: No specific ADI or MSDI reported; usage in flavors is typically low, minimizing exposure risk.
• Dermal Exposure: Limited data on irritation or sensitization; generally considered safe at typical fragrance concentrations.
• Inhalation Exposure: Volatile nature suggests potential for inhalation exposure; occupational safety measures recommended in manufacturing settings.
• Risk Profiles: Generally similar for food and fragrance applications, with low exposure levels reducing risk.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

• Why This Material is Valuable: Isocyclocitral provides a unique fresh and citrus-like note that enhances both flavor and fragrance compositions.
• Typical Synergies: Works well with other citrus and floral compounds to create balanced and complex profiles.
• Common Formulation Pitfalls: Overuse can lead to overpowering citrus notes; careful balancing is required.
• Situations Where It is Frequently Over- or Under-Used: Often under-used in complex formulations where its fresh note can provide a needed lift.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

• Well-Established Data: Basic chemical and sensory properties are well-documented.
• Industry-Typical but Undocumented Practices: Usage levels and regulatory status often based on industry norms rather than explicit documentation.
• Known Data Gaps or Regulatory Ambiguities: Specific regulatory approvals and toxicological data are limited.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-04-15 07:33:41 GMT (p2)