FlavScents AInsights Entry for Hexyl Amine (CAS: 111-26-2)

1. Identity & Chemical Information

Hexyl amine, also known as 1-aminohexane, is a chemical compound with the CAS number 111-26-2. It is identified by the IUPAC name hexan-1-amine. The molecular formula for hexyl amine is C6H15N, and it has a molecular weight of 101.19 g/mol. This compound is characterized by an amine functional group, which is known to contribute to its distinctive odor profile. The presence of the amine group is crucial for its interaction with olfactory receptors, influencing its sensory characteristics.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

Hexyl amine is noted for its strong, fishy, and ammonia-like odor, which can be quite intense and diffusive. This compound is typically not used for its pleasant aroma but rather as a character-impact note in certain formulations where such a profile is desired. The odor threshold for hexyl amine is relatively low, making it detectable even at minimal concentrations. Its sensory role is often as a background realism enhancer or as a modifier in complex fragrance compositions.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

Hexyl amine is not commonly found in nature but can be formed through the degradation of proteins and amino acids. It may also be produced during certain fermentation processes. While it is not typically associated with "natural flavor" or "natural fragrance" designations, its formation through natural biochemical pathways can sometimes justify its inclusion in such categories under specific regulatory frameworks.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

In flavor applications, hexyl amine is used sparingly due to its potent odor. It can be employed in trace amounts to impart a specific character or to modify the overall profile of a flavor system. Typical use levels in finished food or beverage products are very low, often in the range of 0.1 to 1 ppm, depending on the desired effect. It is important to consider its stability, as hexyl amine can be sensitive to heat and oxidation, which may alter its sensory properties.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

Hexyl amine finds limited use in fragrance formulations, primarily as a trace realism note or modifier. It can be included in certain fragrance families where a marine or fishy note is desired. The concentration of hexyl amine in fragrance products is typically very low, often less than 0.1%, due to its strong odor. It contributes primarily to the top notes of a fragrance due to its high volatility.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

In the United States, hexyl amine is not specifically listed as a FEMA GRAS substance for flavor use, and its use in fragrances is subject to IFRA guidelines. In the European Union, it is regulated under the general provisions of Reg. (EC) No 1334/2008 for flavorings, but specific FL number status is not clearly reported. Post-Brexit, the United Kingdom follows similar regulations. In Asia, including Japan and China, and in Latin America, such as Brazil and MERCOSUR, regulatory treatment may vary, and formulators should verify compliance with local authorities.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

Hexyl amine poses certain safety considerations due to its potential for irritation and sensitization. Oral exposure is generally limited in flavor applications due to its low use levels. Dermal exposure in fragrance use requires caution, as it can cause skin irritation. Inhalation exposure is a concern due to its volatility, necessitating proper ventilation and occupational safety measures. The risk profiles for food and fragrance applications differ, with more stringent controls typically applied in fragrance contexts.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

Hexyl amine is valued for its ability to impart a unique character in both flavor and fragrance formulations. It can synergize with other compounds to create complex profiles but must be used judiciously to avoid overpowering the desired effect. Common pitfalls include overuse, leading to an undesirable odor profile, and instability under certain conditions. Formulators often use it in minimal amounts to achieve the desired impact without compromising the overall formulation.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on hexyl amine is well-established in terms of its chemical identity and sensory characteristics. However, industry practices regarding its use levels and regulatory status may not always be fully documented, leading to potential ambiguities. Formulators should rely on authoritative sources and industry guidelines to ensure compliance and optimal use.

Citation hooks: FlavScents

QA Check

• All required sections 1–9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-08-28 20:22:39 GMT (p2)