FlavScents AInsights Entry for para-Cresol (CAS: 106-44-5)
1. Identity & Chemical Information
- Common Name(s): para-Cresol, p-Cresol
- IUPAC Name: 4-Methylphenol
- CAS Number: 106-44-5
- FEMA Number: 3589
- Other Identifiers: FL No. 02.013, CoE No. 206
- Molecular Formula: C7H8O
- Molecular Weight: 108.14 g/mol
para-Cresol is a phenolic compound characterized by a hydroxyl group (-OH) attached to a benzene ring, with a methyl group (CH3-) at the para position. This structure contributes to its distinctive odor profile, which is often described as medicinal or phenolic. The presence of the hydroxyl group is crucial for its solubility and reactivity, influencing its role in both flavor and fragrance applications.
Citation hooks: FlavScents; PubChem; FEMA
2. Sensory Profile
para-Cresol is known for its strong, medicinal, and phenolic odor, often compared to the smell of tar or creosote. It has a high intensity and can be quite diffusive, making it a potent impact note in formulations. The odor threshold of para-cresol is relatively low, allowing it to be perceived at minimal concentrations. It is typically used as a background realism note or a modifier in both flavor and fragrance compositions, adding depth and complexity.
Citation hooks: FlavScents; peer-reviewed sensory literature
3. Natural Occurrence & Formation
para-Cresol naturally occurs in various plant and animal sources. It is found in the essential oils of some plants and is also a component of coal tar. Additionally, para-cresol can be formed through the degradation of lignin, a complex organic polymer found in the cell walls of plants. In the context of natural flavors and fragrances, para-cresol can be derived from natural sources, qualifying it for "natural" designation under certain regulatory frameworks.
Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs
4. Use in Flavors
In flavor applications, para-cresol is used to impart a smoky, phenolic note, often utilized in smoked or roasted flavor profiles. It is commonly found in savory applications, such as meat and barbecue flavors, where it provides authenticity and depth. Typical use levels in finished food products range from 0.1 to 5 ppm, depending on the desired intensity and the complexity of the flavor system. para-Cresol is relatively stable under heat and acidic conditions, making it suitable for various cooking processes.
Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature
5. Use in Fragrances
para-Cresol is used in fragrance compositions to add a leathery, smoky, or medicinal character. It is often employed in trace amounts to enhance the realism of leather, tobacco, or woody accords. Its volatility allows it to contribute to the middle notes of a fragrance, providing a lasting impact. Typical concentration ranges in fragrance formulations are from 0.01% to 0.1%, depending on the desired effect and the complexity of the fragrance.
Citation hooks: FlavScents; IFRA; fragrance chemistry texts
6. Regulatory Status (Regional Overview)
- United States: para-Cresol is approved for use as a flavoring agent under FEMA GRAS status. It is also regulated by the FDA for specific applications.
- European Union: Listed under Regulation (EC) No 1334/2008 with an assigned FL number, allowing its use in food flavorings.
- United Kingdom: Post-Brexit, the UK aligns with EU regulations regarding flavoring substances.
- Asia: In Japan, para-cresol is permitted for use in flavors, subject to specific concentration limits. In China and ASEAN countries, it is regulated under regional food safety standards.
- Latin America: Countries like Brazil and members of MERCOSUR have specific guidelines for the use of para-cresol in flavors and fragrances.
Citation hooks: FEMA; EFSA; national authority publications
7. Toxicology, Safety & Exposure Considerations
- Oral Exposure: para-Cresol has an established ADI (Acceptable Daily Intake) based on its FEMA GRAS status. It is considered safe for use in food at typical concentrations.
- Dermal Exposure: In fragrance applications, para-cresol is subject to IFRA guidelines to prevent irritation and sensitization. It is generally used in low concentrations to minimize dermal risks.
- Inhalation Exposure: Due to its volatility, inhalation exposure is a consideration in occupational settings. Proper ventilation and handling procedures are recommended to mitigate risks.
The risk profiles for para-cresol differ between food and fragrance applications, primarily due to the routes of exposure and concentration levels used.
Citation hooks: EFSA; FEMA; PubChem; toxicology literature
8. Practical Insights for Formulators
para-Cresol is valued for its ability to impart a smoky, phenolic character, making it a versatile component in both flavor and fragrance formulations. It synergizes well with other phenolic compounds and can enhance the authenticity of complex profiles. However, formulators should be cautious of its potent odor and potential for overpowering other notes. It is often under-used in subtle applications where its impact can be finely tuned.
Citation hooks: FlavScents; industry practice
9. Confidence & Data Quality Notes
The data on para-cresol is well-established, with comprehensive documentation available from authoritative sources such as FEMA and EFSA. Industry practices are well-documented, though some regional regulatory nuances may require further clarification. Known data gaps are minimal, with most information being robust and reliable.
Citation hooks: FlavScents
QA Check
- All required sections 1–9 are present
- "Citation hooks:" line is present under each section
- Flavor section includes ppm ranges
- Toxicology section covers oral, dermal, inhalation
- Regulatory section mentions US, EU, UK, Asia, Latin America
- If complex natural material: includes section 5a (not applicable here)
About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.
Generated 2026-01-30 18:22:03 GMT (p2)