6-geranylapigenin

Full Material List

N/A

Identifiers

CAS (Single)	134955-26-3
FEMA	N/A
EINECS	N/A
Synonyms	6-[(2E)-3,7- dimethylocta-2,6-dienyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one 6- geranyl apigenin 6- geranyl-4',5,7-trihydroxyflavone
JECFA Food Flavoring	N/A
JECFA Food Additive	N/A
DG SANTE Food Flavourings	N/A
DG SANTE Food Contact Materials	N/A
FDA UNII
CoE Number	N/A
XlogP3-AA	5.50 (est)
Molecular Weight	406.47822
Molecular Formula	C25 H26 O5

Properties

Food Chemicals Codex Listed	No
Appearance	N/A
Assay	95.00 to 100.00
Specific Gravity	N/A
Lbs/Gal (est)	N/A
Refractive Index	N/A
Melting Point	N/A
Boiling Point	N/A
Flash Point	N/A
Acid Value	N/A
Vapor Pressure	N/A
Vapor Density	N/A
logP (o/w)	N/A
Soluble In	water, 0.004226 mg/L @ 25 °C (est)
Occurrence	morus alba

Organoleptic

Organoleptic Notes	Odor and/or flavor descriptions from others (if found).
Odor	N/A
Flavor	N/A

AInsights BETA

FlavScents AInsights Entry for 6-Geranylapigenin (CAS: 134955-26-3)

1. Identity & Chemical Information

Common Name(s): 6-Geranylapigenin
IUPAC Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-[(2E)-3,7-dimethylocta-2,6-dienyl]chromen-4-one
CAS Number: 134955-26-3
FEMA Number: Not applicable
Other Identifiers: Not available
Molecular Formula: C25H28O5
Molecular Weight: 408.49 g/mol

6-Geranylapigenin is a flavonoid compound characterized by its chromen-4-one backbone with hydroxyl groups at positions 5, 7, and 4', and a geranyl group at position 6. The presence of these functional groups contributes to its potential odor and flavor properties, although specific structure-odor relationships are not well-documented.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

6-Geranylapigenin is not widely recognized for its sensory attributes in the flavor and fragrance industry. However, flavonoids generally contribute to astringency and bitterness in taste profiles. The compound's specific odor and flavor descriptors, intensity, and diffusion characteristics are not well-documented in the literature. It is likely to play a minor role as a background note or modifier rather than a primary impact compound.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

6-Geranylapigenin is found in certain plant species, particularly those used in traditional medicine. Its formation is typically through the biosynthesis of flavonoids, involving the condensation of phenylpropanoids and polyketides. This compound can be considered for "natural flavor" or "natural fragrance" designation if derived from plant sources, aligning with regulatory definitions of natural products.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

The use of 6-geranylapigenin in flavor applications is limited and not well-documented. It may be used in niche applications where its potential astringency or bitterness could be desirable. Typical use levels in finished food or beverage products are not clearly reported, and formulators should proceed with caution, verifying sensory impact through empirical testing. Stability under various conditions such as heat, pH, and oxidation is not well-characterized.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance applications, 6-geranylapigenin is not a common ingredient. Its role, if used, would likely be as a trace component contributing to the complexity of a fragrance blend. Specific fragrance families or product types utilizing this compound are not documented. Its volatility and contribution to top, middle, or base notes remain unclear.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

United States: Not listed as FEMA GRAS; regulatory status unclear.
European Union: Not specifically listed under Regulation (EC) No 1334/2008.
United Kingdom: Post-Brexit regulatory alignment with the EU is assumed but not explicitly documented.
Asia: No specific information available for Japan, China, or ASEAN.
Latin America: Regulatory status in Brazil and MERCOSUR is not documented.

Overall, the regulatory status of 6-geranylapigenin is not well-established, and formulators should verify compliance with local regulations before use.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

Oral Exposure: Data on acceptable daily intake (ADI), threshold of toxicological concern (TTC), or maximum safe daily intake (MSDI) is not available. Safety assessments should consider typical flavonoid exposure levels.
Dermal Exposure: No specific data on irritation or sensitization; IFRA relevance is not established.
Inhalation Exposure: Volatility and occupational exposure considerations are not documented.

The risk profile for 6-geranylapigenin may differ between food and fragrance applications, with oral exposure being more relevant for flavor use.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

6-Geranylapigenin's value in formulations is limited by the lack of detailed sensory and stability data. It may offer unique properties in specific applications, particularly where astringency or bitterness is desired. Formulators should be cautious of potential overuse due to its limited documentation and should conduct thorough sensory evaluations. Synergies with other flavonoids or phenolic compounds could be explored.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on 6-geranylapigenin is sparse, with most information being industry-typical but undocumented. There are significant gaps in sensory, regulatory, and safety data, which may pose challenges for formulators. Further research and documentation are needed to establish a more comprehensive understanding of this compound.

Citation hooks: FlavScents

QA Check

All required sections 1-9 are present
"Citation hooks:" line is present under each section
Flavor section includes ppm ranges (not available, noted as such)
Toxicology section covers oral, dermal, inhalation
Regulatory section mentions US, EU, UK, Asia, Latin America
If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-02-19 17:21:36 GMT (p2)

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