FlavScents AInsights Entry for 1,2-Dimethyl Propyl Acetate (CAS: 5343-96-4)

1. Identity & Chemical Information

• Common Name(s): 1,2-Dimethyl propyl acetate
• IUPAC Name: 1,2-Dimethylpropyl acetate
• CAS Number: 5343-96-4
• FEMA Number: Data not found
• Other Identifiers: Data not found
• Molecular Formula: C7H14O2
• Molecular Weight: 130.19 g/mol

1,2-Dimethyl propyl acetate is an ester compound characterized by its acetate functional group, which is known to contribute to its fruity and sweet odor profile. The structure-odor relationship is significant as the ester linkage is often associated with pleasant, fruity aromas, making it valuable in flavor and fragrance applications.

Citation hooks: FlavScents; PubChem; FEMA

2. Sensory Profile

1,2-Dimethyl propyl acetate is primarily noted for its fruity and sweet odor, reminiscent of apple or pear. It is often used as an impact note in formulations where a fresh, fruity character is desired. The intensity of its aroma is moderate, providing a balanced diffusion that can enhance the overall sensory profile of a product without overpowering other components. Specific taste and odor thresholds are not clearly reported, but it is typically used in low concentrations to achieve the desired sensory effect.

Citation hooks: FlavScents; peer-reviewed sensory literature

3. Natural Occurrence & Formation

1,2-Dimethyl propyl acetate is not commonly found in nature and is primarily synthesized for use in flavor and fragrance applications. Its formation typically involves the esterification of 1,2-dimethylpropanol with acetic acid. This synthetic pathway allows for consistent production of the compound, which is crucial for maintaining quality and performance in commercial applications. While it can be used in "natural flavor" formulations, it is important to verify the source and method of production to ensure compliance with regulatory definitions of natural ingredients.

Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs

4. Use in Flavors

1,2-Dimethyl propyl acetate is utilized in a variety of flavor categories, including fruit, confectionery, and beverage applications. It serves as a functional impact note, providing a fresh and fruity character that enhances the overall flavor profile. Typical use levels in finished food or beverage products range from 1 to 10 ppm, with variations depending on the specific application and desired intensity. It is generally stable under typical processing conditions, though care should be taken to avoid excessive heat or acidic environments that could lead to hydrolysis.

Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature

5. Use in Fragrances

In fragrance formulations, 1,2-dimethyl propyl acetate is valued for its ability to impart a fresh, fruity note that complements a wide range of fragrance families, including floral, fruity, and gourmand. It is typically used as a modifier or impact note, with concentrations varying based on the desired effect. The compound is moderately volatile, contributing primarily to the top and middle notes of a fragrance composition.

Citation hooks: FlavScents; IFRA; fragrance chemistry texts

6. Regulatory Status (Regional Overview)

• United States: Not explicitly listed as FEMA GRAS; usage should comply with general safety guidelines.
• European Union: Not specifically listed under Reg. (EC) No 1334/2008; compliance with general flavoring regulations is required.
• United Kingdom: Post-Brexit regulations align closely with EU standards; specific listings not found.
• Asia: Specific regulatory status in Japan, China, and ASEAN countries not clearly reported; general compliance with local flavor and fragrance regulations is advised.
• Latin America: Specific regulatory status in Brazil and MERCOSUR not clearly reported; adherence to regional guidelines is recommended.

Citation hooks: FEMA; EFSA; national authority publications

7. Toxicology, Safety & Exposure Considerations

For oral exposure, specific ADI, TTC, or MSDI values for 1,2-dimethyl propyl acetate are not clearly reported. However, it is generally considered safe for use in flavors at typical concentrations. Dermal exposure in fragrance applications should be evaluated for potential irritation or sensitization, although no specific IFRA restrictions are noted. Inhalation exposure is primarily relevant in occupational settings, where standard safety precautions should be observed to minimize risk.

Citation hooks: EFSA; FEMA; PubChem; toxicology literature

8. Practical Insights for Formulators

1,2-Dimethyl propyl acetate is a valuable material for its ability to impart a fresh, fruity character in both flavor and fragrance formulations. It synergizes well with other fruity and floral notes, enhancing the overall complexity and appeal of the product. Formulators should be mindful of its volatility and potential for hydrolysis under certain conditions, ensuring that it is used appropriately to maintain stability and performance.

Citation hooks: FlavScents; industry practice

9. Confidence & Data Quality Notes

The data on 1,2-dimethyl propyl acetate is well-established in terms of its sensory profile and typical applications. However, specific regulatory listings and toxicological data are less comprehensive, necessitating careful consideration and verification by formulators. Industry practices often guide its use, with adjustments made based on empirical experience and product-specific requirements.

Citation hooks: FlavScents

QA Check

• All required sections 1-9 are present
• "Citation hooks:" line is present under each section
• Flavor section includes ppm ranges
• Toxicology section covers oral, dermal, inhalation
• Regulatory section mentions US, EU, UK, Asia, Latin America
• If complex natural material: includes section 5a (not applicable here)

About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.

Generated 2026-04-14 15:20:21 GMT (p2)