FlavScents AInsights Entry for 2,5-Dimethyl-3-furan thiol (CAS: 55764-23-3)
1. Identity & Chemical Information
- Common Name(s): 2,5-Dimethyl-3-furan thiol
- IUPAC Name: 2,5-Dimethylfuran-3-thiol
- CAS Number: 55764-23-3
- FEMA Number: Not available
- Other Identifiers: Not available
- Molecular Formula: C6H8OS
- Molecular Weight: 128.19 g/mol
2,5-Dimethyl-3-furan thiol is characterized by its thiol group attached to a furan ring, contributing to its potent odor profile. The presence of the thiol group is crucial for its strong, savory aroma, often described as reminiscent of roasted or cooked meat, which is significant in flavor applications.
Citation hooks: FlavScents; PubChem; FEMA
2. Sensory Profile
2,5-Dimethyl-3-furan thiol is known for its intense, savory aroma, often described as meaty, roasted, or reminiscent of cooked beef. It has a powerful odor with a low detection threshold, making it an impactful note in flavor formulations. Its sensory role is typically as an impact note, providing depth and authenticity to savory flavors.
Citation hooks: FlavScents; peer-reviewed sensory literature
3. Natural Occurrence & Formation
This compound is naturally found in cooked meat and is a product of the Maillard reaction, a chemical reaction between amino acids and reducing sugars that occurs during cooking. Its presence in natural sources like roasted coffee and meat juices contributes to its designation as a "natural flavor" in certain contexts.
Citation hooks: FlavScents; food chemistry literature; EFSA/JECFA monographs
4. Use in Flavors
2,5-Dimethyl-3-furan thiol is primarily used in savory flavor applications, such as meat, poultry, and roasted profiles. It serves as an impact note, enhancing the authenticity of these flavors. Typical use levels in finished food products range from 0.1 to 5 ppm, depending on the desired intensity and the complexity of the flavor system. It is relatively stable under typical cooking conditions but can degrade under extreme heat or prolonged exposure to air.
Citation hooks: FlavScents; FEMA GRAS documentation; formulation literature
5. Use in Fragrances
In fragrances, 2,5-dimethyl-3-furan thiol is less commonly used due to its potent and specific aroma profile. When used, it contributes to the realism of savory or gourmand fragrance compositions, often as a trace realism note. Its volatility places it in the top note category, where it can provide an initial burst of savory aroma.
Citation hooks: FlavScents; IFRA; fragrance chemistry texts
6. Regulatory Status (Regional Overview)
- United States: Not explicitly listed as FEMA GRAS; usage in flavors may be subject to general safety evaluations.
- European Union: Not specifically listed under Regulation (EC) No 1334/2008; may be used under general flavoring guidelines.
- United Kingdom: Follows EU regulations post-Brexit with no significant divergence reported.
- Asia: Limited specific data; general flavoring guidelines apply.
- Latin America: Usage subject to national regulations; no specific listings found.
Citation hooks: FEMA; EFSA; national authority publications
7. Toxicology, Safety & Exposure Considerations
- Oral Exposure: No specific ADI or MSDI established; usage should be guided by general safety evaluations and industry practices.
- Dermal Exposure: Limited data on irritation or sensitization; not typically used in direct skin applications.
- Inhalation Exposure: Volatility suggests potential for inhalation exposure; occupational safety measures should be considered in manufacturing settings.
Risk profiles may differ between food and fragrance applications, with more stringent evaluations typically applied to flavor use.
Citation hooks: EFSA; FEMA; PubChem; toxicology literature
8. Practical Insights for Formulators
2,5-Dimethyl-3-furan thiol is valued for its ability to impart a realistic, savory note to flavor formulations. It synergizes well with other Maillard reaction products and can enhance the depth of meat and roasted profiles. Formulators should be cautious of its potency, as overuse can lead to an overpowering aroma. It is often under-used in complex flavor systems where subtlety is required.
Citation hooks: FlavScents; industry practice
9. Confidence & Data Quality Notes
Data on 2,5-dimethyl-3-furan thiol is well-established in terms of its sensory profile and natural occurrence. However, specific regulatory approvals and toxicological data are less documented, requiring formulators to rely on industry-typical practices and general safety evaluations.
Citation hooks: FlavScents
QA Check
- [x] All required sections 1-9 are present
- [x] "Citation hooks:" line is present under each section
- [x] Flavor section includes ppm ranges
- [x] Toxicology section covers oral, dermal, inhalation
- [x] Regulatory section mentions US, EU, UK, Asia, Latin America
- [x] If complex natural material: includes section 5a (not applicable here)
About FlavScents AInsights (Disclosure)
FlavScents AInsights integrates information from authoritative government, scientific, academic, and industry sources to provide applied, exposure-aware insight into flavor and fragrance materials. Data are drawn from regulatory bodies, expert safety panels, peer-reviewed literature, public chemical databases, and long-standing professional practice within the flavor and fragrance community. Where explicit published values exist, they are reported directly; where gaps remain, AInsights reflects widely accepted industry-typical practice derived from convergent sensory behavior, historical commercial use, regulatory non-objection, and expert consensus. All such information is clearly labeled to distinguish documented data from professional guidance or informed estimation, with the goal of offering transparent, practical, and scientifically responsible context for researchers, formulators, and regulatory specialists. This section is generated using advanced computational language modeling to synthesize and structure information from established scientific and regulatory knowledge bases, with the intent of supporting—not replacing—expert review and judgment.
Generated 2026-02-26 09:26:17 GMT (p2)
